{"id":3689,"date":"2020-12-03T11:10:00","date_gmt":"2020-12-03T11:10:00","guid":{"rendered":"https:\/\/aboutsmallruminants.com\/?p=3689"},"modified":"2021-04-15T04:13:50","modified_gmt":"2021-04-15T04:13:50","slug":"prevencion-aborto-enzootico-vacunas-chlamydia","status":"publish","type":"post","link":"https:\/\/aboutsmallruminants.com\/es\/prevencion-aborto-enzootico-vacunas-chlamydia\/","title":{"rendered":"PASADO, PRESENTE Y FUTURO DE LAS VACUNAS DE CLAMIDIAS"},"content":{"rendered":"<div class=\"intro-text\"><strong>\u00bfQu\u00e9 seguridad nos ofrecen las vacunas vivas atenuadas? \u00bfQu\u00e9 eficacia tienen las vacunas inactivadas? \u00bfC\u00f3mo conseguir una vacuna eficaz y segura que nos ayude al control de dicho problema? En el siguiente video, la Dra. Maria Rosa Caro, Catedr\u00e1tica de Sanidad Animal en la Universidad de Murcia, investigadora con multitud de estudios reconocidos internacionalmente relacionados con infecciones clamidiales, analiza en profundidad el pasado, presente de dichas vacunas y las claves para obtener la vacuna ideal contra <em>Chlamydia abortus<\/em>.<\/strong><\/div>\n<p>&nbsp;<\/p>\n<p>En el siguiente v\u00eddeo, la <strong>Dra. Caro<\/strong> nos explica <strong>conceptos clave de las vacunas vivas atenuadas<\/strong> y analiza algunas publicaciones cient\u00edficas de la \u00faltima d\u00e9cada en las que se cuestiona la seguridad de dichas vacunas.<\/p>\n<p>Tambi\u00e9n, nos explica los requisitos para obtener la vacuna ideal contra <em>Chlamydia abortus<\/em>.<\/p>\n<div class=\"jeg_video_container jeg_video_content\"><iframe loading=\"lazy\" title=\"Vacunas de clamidias: pasado, presente y futuro\" width=\"500\" height=\"281\" src=\"https:\/\/www.youtube.com\/embed\/mmGhBn2HB2g?feature=oembed\" frameborder=\"0\" allow=\"accelerometer; autoplay; clipboard-write; encrypted-media; gyroscope; picture-in-picture; web-share\" referrerpolicy=\"strict-origin-when-cross-origin\" allowfullscreen><\/iframe><\/div>\n<p>&nbsp;<\/p>\n<h2>VACUNAS VIVAS ATENUADAS<\/h2>\n<p>En el v\u00eddeo, la Dra. Caro expone algunos de los principales inconvenientes de las vacunas vivas atenuadas:<\/p>\n<p>&#8211; Posible riesgo de <strong>transmisi\u00f3n al hombre<\/strong> (Zoonosis).<br \/>\n&#8211; <strong>No administraci\u00f3n<\/strong> en animales gestantes.<br \/>\n&#8211; <strong>No administraci\u00f3n<\/strong> en animales con tratamientos antibi\u00f3ticos.<br \/>\n&#8211; <strong>No mezclar animales<\/strong> vacunados con no vacunados.<br \/>\n&#8211; <strong>No interrumpir<\/strong> la cadena de fr\u00edo.<\/p>\n<p>&nbsp;<\/p>\n<h2>PUBLICACIONES SOBRE CEPAS VACUNAL 1B (VACUNA VIVA ATENUADA)<\/h2>\n<p>Entre los a\u00f1os 1990 y 2000 se describen algunos casos de <strong>abortos por clamidias en reba\u00f1os vacunados<\/strong> en Reino Unido, Francia y Espa\u00f1a, pero se desconoc\u00eda el porqu\u00e9.<\/p>\n<p>Gracias al desarrollo de la t\u00e9cnica PCR-RFLP por parte de la Dra. Karine Laroucau, se pudo realizar un diagn\u00f3stico diferencial entre cepas vacunales y cepas salvajes de <em>Chlamydia abortus<\/em>.<\/p>\n<p>Esto permiti\u00f3 estudios posteriores, que confirmaban una relaci\u00f3n entre el <strong>uso de vacunas vivas atenuadas<\/strong> y la aparici\u00f3n de <strong>tormentas de abortos<\/strong> en reba\u00f1os de Escocia (<a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0264410X10006729?via%3Dihub\" target=\"_blank\" rel=\"noopener noreferrer\"><em>Wheelhouse at al.<\/em><\/a>) y Francia (<a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0378113518304711?via%3Dihub\" target=\"_blank\" rel=\"noopener noreferrer\"><em>Laroucau at al.<\/em><\/a>).<\/p>\n<blockquote class=\"pullquote align-center\"><p><strong><span style=\"font-size: 20pt;\">\u201cEn 2018, la Dra. Laroucau confirma que la cepa vacunal 1B causa un brote de abortos y adem\u00e1s, circula en el reba\u00f1o, infectando animales no vacunados\u201d<\/span><\/strong><\/p><\/blockquote>\n<p>Posteriormente, el genetista <strong>Dr. David Longbottom<\/strong> (<a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0264410X18306625?via%3Dihub\" target=\"_blank\" rel=\"noopener noreferrer\"><em>Longbottom at al.<\/em><\/a>), tras un an\u00e1lisis gen\u00f3mico completo de las diferentes cepas (vacunal y salvaje), confirma lo que muchos cient\u00edficos sospechaban: la <strong>cepa vacunal<\/strong> 1B inclu\u00edda en las vacunas vivas no est\u00e1 atenuada, pudiendo potencialmente <strong>causar abortos e infectar<\/strong> otros animales.<\/p>\n<blockquote class=\"pullquote align-center\"><p><strong><span style=\"font-size: 20pt;\">\u201cDavid Longbottom, confirma en 2018 que la cepa vacunal 1B NO est\u00e1 atenuada\u201d<\/span><\/strong><\/p><\/blockquote>\n<h2>\u00bfC\u00d3MO CONSEGUIR UNA MEJOR VACUNA INACTIVADA FRENTE A <em>CHLAMYDIA ABORTUS<\/em>?<\/h2>\n<p>La Dra. Caro se\u00f1ala como imprescindibles tres puntos a la hora de dise\u00f1ar una vacuna inactivada eficaz:<\/p>\n<p>&#8211; Concentraci\u00f3n de ant\u00edgeno.<br \/>\n&#8211; Adecuado <strong>m\u00e9todo de inactivaci\u00f3n<\/strong>.<br \/>\n&#8211; <strong>Adyuvante<\/strong> que potencie la inmunidad celular.<\/p>\n<p>Como conclusi\u00f3n, podemos extraer de la ponencia de la Dra. Caro, que la vacuna ideal deber\u00e1 ser una vacuna <strong>eficaz<\/strong>, <strong>segura<\/strong>, <strong>estable<\/strong> y cuyo <strong>coste de producci\u00f3n no sea elevado<\/strong> y as\u00ed evitar un coste elevado para el ganadero.<\/p>\n<p>Posteriormente a este evento, se lanz\u00f3 al mercado una <a href=\"https:\/\/www.hipra.com\/portal\/hipra\/knowledge\/bgdetail\/infectious-abortions-sheep\/infectious-abortions-sheep-vaccination\/!ut\/p\/z1\/tVLBcoIwFPyWHjxmEhLEeMSWwdJSnVpUuDgxiRCVgIha_77Rm3XEdjrNLfP27b7dWZjAKUw026uU1arQbG3-ceLMArfv-T7Fr8jp9JD70R979MXHds-BkyaAjy2Y_GQf3Xguurc_hglMSq4EjLsCL7AQXWAh7AAbSwHmnHBAqU0JE11KCDuhua7LOoOx1C200sVhLUUqW2jO-Cqtip0WLaT0QnITwW4L2LyoTmFswTaTsmyagT3jXOlzdjC4d7mJFlfhY5ia-1mdAcNbwOlt9qbZhbIhVsvNJnGN1ULX8rOG0__1OjnFeuG2_dw2br2BTYeYDDC5Alz35AxoKMJIahibtnRuhvpuwcleyQOMdFHlpr2jX5ajj74r-F5kGYVgEAajN3Qu7J8UyjyKckra6-WRIDXM0nz21Avdhy92oExC\/dz\/d5\/L2dBISEvZ0FBIS9nQSEh\/?urile=wcm%3Aoid%3A9d2f2dd9-1026-42ed-bc3c-88483ad9833a\" target=\"_blank\" rel=\"noopener noreferrer\">vacuna inactivada<\/a> que cumple dichos requisitos.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u00bfQu\u00e9 seguridad nos ofrecen las vacunas vivas atenuadas? \u00bfQu\u00e9 eficacia tienen las vacunas inactivadas? \u00bfC\u00f3mo conseguir una vacuna eficaz y segura que nos ayude al control de dicho problema? En el siguiente video, la Dra. Maria Rosa Caro, Catedr\u00e1tica de Sanidad Animal en la Universidad de Murcia, investigadora con multitud de estudios reconocidos internacionalmente relacionados [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":4321,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[38],"tags":[],"class_list":["post-3689","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-abortos-enfermedades-reproductivas-ovejas-cabras"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v26.5 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Prevenci\u00f3n del Aborto Enzo\u00f3tico: vacunas contra clamidia | Small Ruminants<\/title>\n<meta name=\"description\" content=\"Relaci\u00f3n entre las vacunas vivas atenuadas y la aparici\u00f3n de cepas vacunales en tormentas de abortos \u00bfC\u00f3mo mejorar las vacunas frente a Chlamydia en ovino?\" 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