{"id":26353,"date":"2024-09-25T06:51:09","date_gmt":"2024-09-25T06:51:09","guid":{"rendered":"https:\/\/aboutsmallruminants.com\/?p=26353"},"modified":"2024-09-25T06:57:13","modified_gmt":"2024-09-25T06:57:13","slug":"securite-au-cours-du-dernier-mois-de-gestation-dun-vaccin-inactive-contre-la-chlamydia","status":"publish","type":"post","link":"https:\/\/aboutsmallruminants.com\/fr\/securite-au-cours-du-dernier-mois-de-gestation-dun-vaccin-inactive-contre-la-chlamydia\/","title":{"rendered":"Une \u00e9tude confirme la s\u00e9curit\u00e9 au cours du dernier mois de gestation d\u2019un vaccin inactiv\u00e9 contre la Chlamydia"},"content":{"rendered":"
\n

La vaccination contre la Chlamydia est recommand\u00e9e avant l\u2019accouplement, mais la vaccination \u00e0 un autre moment est souvent in\u00e9vitable. Cela peut impliquer la vaccination des femelles gestantes, et des questions peuvent se poser quant \u00e0 la s\u00e9curit\u00e9 du vaccin. R\u00e9cemment, une \u00e9tude a \u00e9t\u00e9 pr\u00e9sent\u00e9e. Elle \u00e9value la s\u00e9curit\u00e9 du vaccin inactiv\u00e9 INMEVA\u00ae, administr\u00e9 aux brebis au cours du dernier mois de gestation.<\/p>\n<\/div>\n

Vaccination contre la Chlamydia<\/h2>\n

L\u2019avortement enzootique des ovins<\/strong>, provoqu\u00e9 par la Chlamydia abortus<\/em><\/strong>, est \u00e0 l\u2019origine d\u2019importantes pertes productives et \u00e9conomiques<\/a>\u00a0dans les \u00e9levages ovins et caprins.<\/p>\n

La vaccination est le moyen le plus efficace de contr\u00f4ler les avortements caus\u00e9s par la Chlamydia<\/p><\/blockquote>\n

Dans la plupart des cas, les protocoles de vaccination<\/strong> sont r\u00e9alis\u00e9s avant l\u2019accouplement, afin d\u2019assurer une protection maximale avant la mise bas.<\/p>\n

Cependant, dans les campagnes, il est parfois n\u00e9cessaire de proc\u00e9der \u00e0 des vaccinations d\u2019urgence<\/strong> pour faire face \u00e0 des \u00e9pid\u00e9mies<\/a>, ce qui peut impliquer la n\u00e9cessit\u00e9 de vacciner au cours du dernier mois<\/strong> de gestation.<\/p>\n

Dans cette situation, des inqui\u00e9tudes et des doutes peuvent surgir quant \u00e0 la s\u00e9curit\u00e9<\/strong> de la vaccination.<\/p>\n

Les vaccins inactiv\u00e9s contre la Chlamydia se caract\u00e9risent par leur haute s\u00e9curit\u00e9<\/p><\/blockquote>\n

Traditionnellement, les vaccins vivants att\u00e9nu\u00e9s<\/strong> contre la Chlamydia ont \u00e9t\u00e9 les plus utilis\u00e9s, mais leur s\u00e9curit\u00e9 a \u00e9t\u00e9 remise en question<\/strong> depuis des cas d\u2019avortements provoqu\u00e9s par la souche vaccinale<\/strong>. 1,2,3<\/sup><\/p>\n

Une \u00e9tude r\u00e9cente visait \u00e0 \u00e9valuer la s\u00e9curit\u00e9 d\u2019INMEVA\u00ae<\/a>, un vaccin inactiv\u00e9<\/strong>, lorsqu\u2019il est administr\u00e9 au cours du dernier mois de gestation.<\/p>\n

 <\/p>\n

Comment cela a-t-il \u00e9t\u00e9 fait ?<\/h2>\n

Au total, 57 brebis gestantes<\/strong> ont particip\u00e9 \u00e0 l\u2019\u00e9tude et \u00e9t\u00e9 r\u00e9parties en 5 groupes<\/strong> dans lesquels diff\u00e9rents protocoles ont \u00e9t\u00e9 r\u00e9alis\u00e9s avec INMEVA\u00ae ou PBS.<\/p>\n

Des donn\u00e9es ont \u00e9t\u00e9 recueillies sur\u00a0: les r\u00e9actions<\/strong> au site d\u2019injection, la temp\u00e9rature<\/strong> syst\u00e9mique et rectale, et les probl\u00e8mes de reproduction<\/strong>.<\/p>\n

\"Protocoles<\/a>
Fig. 1. Protocoles r\u00e9alis\u00e9s dans chaque groupe d\u2019\u00e9tude.<\/figcaption><\/figure>\n

R\u00e9sultats obtenus<\/h2>\n
\"Temp\u00e9rature<\/a>
Fig. 2. Temp\u00e9rature rectale des brebis.<\/figcaption><\/figure>\n

Les r\u00e9sultats de l\u2019\u00e9tude ont \u00e9t\u00e9 tr\u00e8s positifs. La vaccination<\/a>, quel que soit le protocole, n\u2019a provoqu\u00e9 aucune r\u00e9action<\/strong> locale ou syst\u00e9mique visible.<\/p>\n

Une augmentation de la temp\u00e9rature<\/strong> rectale a \u00e9t\u00e9 observ\u00e9e dans tous les groupes 24\u00a0heures apr\u00e8s la vaccination, mais elle s\u2019est normalis\u00e9e dans les 24\u00a0heures suivantes dans tous les cas.<\/p>\n

Aucun groupe n\u2019a pr\u00e9sent\u00e9 de r\u00e9actions locales ou syst\u00e9miques visibles<\/p><\/blockquote>\n

Des probl\u00e8mes de reproduction<\/strong> ont \u00e9t\u00e9 observ\u00e9s dans certains groupes, mais ils n\u2019ont pas \u00e9t\u00e9 consid\u00e9r\u00e9s comme li\u00e9s \u00e0 la vaccination, puisqu\u2019ils \u00e9taient \u00e9galement pr\u00e9sents dans les groupes t\u00e9moins.<\/p>\n

\"Probl\u00e8mes<\/a>
Fig. 3. Probl\u00e8mes de reproduction observ\u00e9s dans l\u2019\u00e9tude.<\/figcaption><\/figure>\n

Certaines brebis des groupes 1 et 4 n\u2019ont pas agnel\u00e9, probablement en raison d\u2019une r\u00e9sorption f\u0153tale<\/strong> en milieu de gestation. Ce fait n\u2019est donc pas non plus imputable au vaccin.<\/p>\n

 <\/p>\n

Conclusions<\/h2>\n

On peut consid\u00e9rer que le vaccin inactiv\u00e9 INMEVA\u00ae est une option s\u00fbre pour une utilisation en urgence au cours du dernier mois de grossesse.<\/p>\n

La vaccination par INMEVA\u00ae<\/a> constitue donc une strat\u00e9gie viable pour lutter contre les \u00e9pid\u00e9mies d\u2019avortements chez les brebis, en fournissant une m\u00e9thode fiable pour prot\u00e9ger les troupeaux m\u00eame en fin de gestation.<\/p>\n

VOIR ETUDE<\/a><\/p>\n

 <\/p>\n

Article r\u00e9dig\u00e9 par :<\/em><\/strong>
\nTania Per\u00e1lvarez Puerta. Global Product Manager, Small Ruminants Franchise \u2013 HIPRA<\/em><\/p>\n

 <\/p>\n

R\u00e9f\u00e9rences bibliographiques :<\/strong><\/p>\n

1. Gaston, S., et al. (2020) The 1B vaccine strain of Chlamydia abortus produces placental pathology indistinguishable from a wild type infection. PLOS ONE, Nov 16, 2020. <\/em>
\n2. Longbottom D. et al. Genomic evidence that the live Chlamydia abortus vaccine strain 1B is not attenuated and has the potential to cause disease. Vaccine 36 (2018) 3593-3598
\n<\/em>3. Laroucou K. et al. Abortion storm induced by the live C. abortus vaccine 1B strain in a vaccinated sheep flock, mimicking a natural wild-type infection. Veterinary Microbiology 225 (2018) 31-33<\/em><\/p>\n","protected":false},"excerpt":{"rendered":"

La vaccination contre la Chlamydia est recommand\u00e9e avant l\u2019accouplement, mais la vaccination \u00e0 un autre moment est souvent in\u00e9vitable. Cela peut impliquer la vaccination des femelles gestantes, et des questions peuvent se poser quant \u00e0 la s\u00e9curit\u00e9 du vaccin. R\u00e9cemment, une \u00e9tude a \u00e9t\u00e9 pr\u00e9sent\u00e9e. Elle \u00e9value la s\u00e9curit\u00e9 du vaccin inactiv\u00e9 INMEVA\u00ae, administr\u00e9 aux brebis au cours du dernier mois de gestation. <\/p>\n","protected":false},"author":10,"featured_media":26516,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[36],"tags":[],"class_list":["post-26353","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-reproduction"],"yoast_head":"\nVaccination contre la Chlamydia au cours du dernier mois de gestation chez la brebis<\/title>\n<meta name=\"description\" content=\"Cette \u00e9tude d\u00e9montre la s\u00e9curit\u00e9 de la vaccination par INMEVA au cours du dernier mois de gestation chez la brebis.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" 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