{"id":3790,"date":"2020-12-03T14:21:03","date_gmt":"2020-12-03T14:21:03","guid":{"rendered":"https:\/\/aboutsmallruminants.com\/?p=3790"},"modified":"2022-08-26T09:25:08","modified_gmt":"2022-08-26T09:25:08","slug":"prevention-avortement-enzootique-vaccins-chlamydia","status":"publish","type":"post","link":"https:\/\/aboutsmallruminants.com\/fr\/prevention-avortement-enzootique-vaccins-chlamydia\/","title":{"rendered":"PASS\u00c9, PR\u00c9SENT ET FUTUR DES VACCINS CONTRE CHLAMYDIA"},"content":{"rendered":"<div class=\"intro-text\"><strong>Quelles garanties nous offrent les vaccins vivants att\u00e9nu\u00e9s ? Quelle est l&rsquo;efficacit\u00e9 des vaccins inactiv\u00e9s ? Comment obtenir un vaccin efficace et s\u00fbr qui nous aide \u00e0 contr\u00f4ler cette infection ? Dans la vid\u00e9o suivante, le Dr. Mar\u00eda Rosa Caro de l&rsquo;universit\u00e9 de Murcie en Espagne, experte reconnue \u00e0 l&rsquo;\u00e9chelle internationale sur les Chlamydia, analyse en profondeur le pass\u00e9 et le pr\u00e9sent de ces vaccins, ainsi que les cl\u00e9s pour obtenir le vaccin adapt\u00e9 contre <em>Chlamydia abortus<\/em>.<\/strong><\/div>\n<p>&nbsp;<\/p>\n<p>Dans la vid\u00e9o suivante, le <strong>Dr. Caro<\/strong> nous explique des concepts cl\u00e9s des <strong>vaccins vivants att\u00e9nu\u00e9s<\/strong> et analyse quelques publications scientifiques des dix derni\u00e8res ann\u00e9es dans lesquelles la s\u00e9curit\u00e9 de ces vaccins est remise en question.<\/p>\n<p>Elle nous explique \u00e9galement les conditions pour obtenir le vaccin adapt\u00e9 contre <em>Chlamydia abortus<\/em>.<\/p>\n<div class=\"jeg_video_container jeg_video_content\"><iframe loading=\"lazy\" title=\"Foro Bovino Rosa Caro - FR\" width=\"500\" height=\"281\" src=\"https:\/\/www.youtube.com\/embed\/0gfdMRHZNjQ?feature=oembed\" frameborder=\"0\" allow=\"accelerometer; autoplay; clipboard-write; encrypted-media; gyroscope; picture-in-picture; web-share\" referrerpolicy=\"strict-origin-when-cross-origin\" allowfullscreen><\/iframe><\/div>\n<p>&nbsp;<\/p>\n<h2>VACCINS VIVANTS ATT\u00c9NU\u00c9S<\/h2>\n<p>Dans la vid\u00e9o, le Dr. Caro pr\u00e9sente certains des <strong>principaux inconv\u00e9nients<\/strong> des <strong>vaccins vivants att\u00e9nu\u00e9s<\/strong> :<\/p>\n<p>&#8211; Risque potentiel de <strong>transmission de la souche vaccinale \u00e0 l&rsquo;homme<\/strong> (zoonose).<br \/>\n&#8211; <strong>Ne pas administrer<\/strong> aux animaux gravides.<br \/>\n&#8211; <strong>Ne pas administrer<\/strong> aux animaux recevant des traitements antibiotiques.<br \/>\n&#8211;<strong> Ne pas m\u00e9langer les animaux<\/strong> vaccin\u00e9s et non vaccin\u00e9s.<br \/>\n&#8211; <strong>Ne pas interrompre<\/strong> la cha\u00eene du froid.<\/p>\n<p>&nbsp;<\/p>\n<h2>PUBLICATIONS SUR LES SOUCHES VACCINALES 1B (VACCIN VIVANT ATT\u00c9NU\u00c9)<\/h2>\n<p>Entre les ann\u00e9es 1990 et 2000, des cas <strong>d&rsquo;avortements par Chlamydia au sein de troupeaux vaccin\u00e9s<\/strong> ont \u00e9t\u00e9 signal\u00e9s au Royaume-Uni, en France et en Espagne, mais la raison en \u00e9tait inconnue.<\/p>\n<p>Gr\u00e2ce au d\u00e9veloppement de la technique PCR-RFLP par le Dr. Karine Laroucau, il a \u00e9t\u00e9 possible de r\u00e9aliser un diagnostic diff\u00e9rentiel entre des souches vaccinales et des souches sauvages de <em>Chlamydia abortus<\/em>.<\/p>\n<p>Cela a permis des \u00e9tudes \u00e0 post\u00e9riori qui ont confirm\u00e9 un lien entre <strong>l&rsquo;utilisation de vaccins vivants att\u00e9nu\u00e9s<\/strong> et l&rsquo;apparition de <strong>vagues d&rsquo;avortements<\/strong> au sein de troupeaux en \u00c9cosse (<a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0264410X10006729?via%3Dihub\" target=\"_blank\" rel=\"noopener noreferrer\"><em>Wheelhouse et al.<\/em><\/a>) et en France (<a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0378113518304711?via%3Dihub\" target=\"_blank\" rel=\"noopener noreferrer\"><em>Laroucau et al.<\/em><\/a>).<\/p>\n<blockquote class=\"pullquote align-center\"><p><strong><span style=\"font-size: 20pt;\">\u201cEn 2018, le Dr. Laroucau confirme que la souche vaccinale 1B cause une \u00e9pid\u00e9mie d&rsquo;avortements et circule au sein du troupeau, infectant des animaux non vaccin\u00e9s\u201d<\/span><\/strong><\/p><\/blockquote>\n<p>Par la suite, le g\u00e9n\u00e9ticien <strong>Dr. David Longbottom<\/strong> (<a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0264410X18306625?via%3Dihub\" target=\"_blank\" rel=\"noopener noreferrer\"><em>Longbottom et al.<\/em><\/a>), apr\u00e8s une analyse g\u00e9nomique compl\u00e8te des diff\u00e9rentes souches (vaccinales et sauvages), confirme ce que de nombreux scientifiques soup\u00e7onnaient : la <strong>souche vaccinale<\/strong> 1B incluse dans les vaccins vivants n&rsquo;est pas att\u00e9nu\u00e9e, elle peut alors <strong>provoquer des avortements spontan\u00e9s et infecter<\/strong> d&rsquo;autres animaux.<\/p>\n<blockquote class=\"pullquote align-center\"><p><strong><span style=\"font-size: 20pt;\">\u201cDavid Longbottom confirme en 2018 que la souche vaccinale 1B n&rsquo;est PAS att\u00e9nu\u00e9e\u201d<\/span><\/strong><\/p><\/blockquote>\n<h2>COMMENT OBTENIR UN MEILLEUR VACCIN INACTIV\u00c9 CONTRE CHLAMYDIA ABORTUS ?<\/h2>\n<p>Le Dr. Caro pr\u00e9sente trois points indispensables pour concevoir un vaccin inactiv\u00e9 efficace :<\/p>\n<p>&#8211; Concentration \u00e9lev\u00e9e d&rsquo;antig\u00e8nes.<br \/>\n&#8211; <strong>M\u00e9thode d&rsquo;inactivation<\/strong> appropri\u00e9e.<br \/>\n&#8211; <strong>Adjuvant<\/strong> qui stimule l&rsquo;immunit\u00e9 cellulaire.<\/p>\n<p>En conclusion, nous pouvons tirer de l&rsquo;expos\u00e9 du Dr. Caro que le vaccin adapt\u00e9 devra \u00eatre un vaccin alliant une meilleure combinaison <strong>efficacit\u00e9<\/strong>, <strong>s\u00e9curit\u00e9<\/strong>, <strong>stabilit\u00e9<\/strong> et avec <strong>un faible co\u00fbt de production<\/strong> de mani\u00e8re \u00e0 le rendre abordable pour les \u00e9leveurs.<\/p>\n<p>Depuis, un <a href=\"https:\/\/www.hipra.com\/portal\/hipra\/knowledge\/bgdetail\/infectious-abortions-sheep\/infectious-abortions-sheep-vaccination\/!ut\/p\/z1\/tVLBcoIwFPyWHjxmEhLEeMSWwdJSnVpUuDgxiRCVgIha_77Rm3XEdjrNLfP27b7dWZjAKUw026uU1arQbG3-ceLMArfv-T7Fr8jp9JD70R979MXHds-BkyaAjy2Y_GQf3Xguurc_hglMSq4EjLsCL7AQXWAh7AAbSwHmnHBAqU0JE11KCDuhua7LOoOx1C200sVhLUUqW2jO-Cqtip0WLaT0QnITwW4L2LyoTmFswTaTsmyagT3jXOlzdjC4d7mJFlfhY5ia-1mdAcNbwOlt9qbZhbIhVsvNJnGN1ULX8rOG0__1OjnFeuG2_dw2br2BTYeYDDC5Alz35AxoKMJIahibtnRuhvpuwcleyQOMdFHlpr2jX5ajj74r-F5kGYVgEAajN3Qu7J8UyjyKckra6-WRIDXM0nz21Avdhy92oExC\/dz\/d5\/L2dBISEvZ0FBIS9nQSEh\/?urile=wcm%3Aoid%3A9d2f2dd9-1026-42ed-bc3c-88483ad9833a\" target=\"_blank\" rel=\"noopener noreferrer\">vaccin inactiv\u00e9<\/a> satisfaisant \u00e0 ces exigences a \u00e9t\u00e9 lanc\u00e9 sur le march\u00e9.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Quelles garanties nous offrent les vaccins vivants att\u00e9nu\u00e9s ? Quelle est l&rsquo;efficacit\u00e9 des vaccins inactiv\u00e9s ? Comment obtenir un vaccin efficace et s\u00fbr qui nous aide \u00e0 contr\u00f4ler cette infection ? Dans la vid\u00e9o suivante, le Dr. Mar\u00eda Rosa Caro de l&rsquo;universit\u00e9 de Murcie en Espagne, experte reconnue \u00e0 l&rsquo;\u00e9chelle internationale sur les Chlamydia, analyse [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":4318,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[36],"tags":[],"class_list":["post-3790","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-reproduction"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v26.5 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Pr\u00e9vention et vaccins de l&#039;avortement enzootique | Small Ruminants<\/title>\n<meta name=\"description\" content=\"Lien entre les vaccins vivants att\u00e9nu\u00e9s et l&#039;identification de souches vaccinales lors de vagues d&#039;avortements.\" \/>\n<meta name=\"robots\" content=\"index, follow, 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