{"id":5348,"date":"2021-06-09T12:48:14","date_gmt":"2021-06-09T12:48:14","guid":{"rendered":"https:\/\/aboutsmallruminants.com\/?p=5348"},"modified":"2021-06-09T12:48:14","modified_gmt":"2021-06-09T12:48:14","slug":"efficacite-vaccin-chlamydia-abortus","status":"publish","type":"post","link":"https:\/\/aboutsmallruminants.com\/fr\/efficacite-vaccin-chlamydia-abortus\/","title":{"rendered":"\u00c9valuation de l\u2019efficacit\u00e9 du dernier vaccin inactiv\u00e9 bient\u00f4t commercialis\u00e9 contre chlamydia abortus"},"content":{"rendered":"<div class=\"intro-text\"><strong><em>Chlamydia abortus<\/em> est le pathog\u00e8ne \u00e0 l\u2019origine de l\u2019avortement enzootique des brebis (AEB), une maladie d\u2019une grande importance \u00e9conomique \u00e0 l\u2019\u00e9chelle mondiale. En 2019, un nouveau vaccin inactiv\u00e9 contre l\u2019AEB a \u00e9t\u00e9 lanc\u00e9\u202f: INMEVA. Dans cet article, nous pr\u00e9sentons les r\u00e9sultats d\u2019une \u00e9tude publi\u00e9e r\u00e9cemment dans la revue scientifique prestigieuse Frontiers in Veterinary Science, qui a \u00e9valu\u00e9 l\u2019efficacit\u00e9 et la s\u00e9curit\u00e9 de ce vaccin.<br \/>\n<\/strong><\/div>\n<p>&nbsp;<\/p>\n<h2>Le pathog\u00e8ne<\/h2>\n<p><a href=\"https:\/\/aboutsmallruminants.com\/fr\/pathones-avortements-brebis-chevres-chlamydia-salmonella\/\" target=\"_blank\" rel=\"noopener noreferrer\"><em>Chlamydia abortus<\/em><\/a> constitue la principale cause d\u2019<strong>avortement chez les petits ruminants<\/strong>. Les signes cliniques sont les suivants\u202f: avortements \u00e0 la fin de la gestation, mortalit\u00e9 n\u00e9onatale, naissances pr\u00e9matur\u00e9es ou naissance d\u2019agneaux faibles.<\/p>\n<blockquote class=\"pullquote align-center\"><p><strong><span style=\"font-size: 20pt;\">\u00abChlamydia abortus est l\u2019une des principales causes d\u2019avortements chez les petits ruminants \u00e0 l\u2019\u00e9chelle mondiale, et provoque d\u2019\u00e9normes pertes \u00e9conomiques\u00bb\u00a0<\/span><\/strong><\/p><\/blockquote>\n<p>Cette maladie se transmet facilement pendant l\u2019agnelage, ce qui entretient le <strong>risque d\u2019infections<\/strong> au sein du troupeau.<\/p>\n<p><a href=\"https:\/\/aboutsmallruminants.com\/wp-content\/uploads\/2021\/06\/efficacy-vaccine-against-enzootic-abortion.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"size-full wp-image-5299 aligncenter\" src=\"https:\/\/aboutsmallruminants.com\/wp-content\/uploads\/2021\/06\/efficacy-vaccine-against-enzootic-abortion.jpg\" alt=\"\" width=\"652\" height=\"367\" srcset=\"https:\/\/aboutsmallruminants.com\/wp-content\/uploads\/2021\/06\/efficacy-vaccine-against-enzootic-abortion.jpg 652w, https:\/\/aboutsmallruminants.com\/wp-content\/uploads\/2021\/06\/efficacy-vaccine-against-enzootic-abortion-300x169.jpg 300w\" sizes=\"auto, (max-width: 652px) 100vw, 652px\" \/><\/a><\/p>\n<p>&nbsp;<\/p>\n<h2>Pourquoi cette \u00e9tude \u00e9tait-elle requise?<\/h2>\n<p>La <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/30322529\/\" target=\"_blank\" rel=\"noopener noreferrer\">s\u00e9curit\u00e9 des vaccins vivants att\u00e9nu\u00e9s<\/a> a r\u00e9cemment \u00e9t\u00e9 remise en cause par la <a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0264410X10006729\" target=\"_blank\" rel=\"noopener noreferrer\">communaut\u00e9 scientifique<\/a>; les vaccins inactiv\u00e9s ont montr\u00e9 une capacit\u00e9 \u00e0 induire l\u2019<strong>immunit\u00e9 chez les brebis<\/strong>, mais leur efficacit\u00e9 a \u00e9t\u00e9 remise en cause, et ils ne sont pas parvenus \u00e0 r\u00e9duire l\u2019excr\u00e9tion.<\/p>\n<blockquote class=\"pullquote align-center\"><p><strong><span style=\"font-size: 20pt;\">\u00abLes vaccins commercialis\u00e9s contre l\u2019AEB pr\u00e9sentaient certains probl\u00e8mes concernant la s\u00e9curit\u00e9 et l\u2019efficacit\u00e9\u00bb\u00a0<\/span><\/strong><\/p><\/blockquote>\n<p>C\u2019est pourquoi cette <a href=\"https:\/\/www.frontiersin.org\/articles\/10.3389\/fvets.2020.00593\/full\" target=\"_blank\" rel=\"noopener noreferrer\">\u00e9tude<\/a> a \u00e9t\u00e9 men\u00e9e, afin d&rsquo;\u00e9valuer l\u2019efficacit\u00e9 et la s\u00e9curit\u00e9 de ce <a href=\"https:\/\/www.hipra.com\/portal\/fr\/hipra\/animalhealth\/products\/detail\/inmeva\" target=\"_blank\" rel=\"noopener noreferrer\">nouveau vaccin inactiv\u00e9, INMEVA<\/a>.<\/p>\n<p>&nbsp;<\/p>\n<h2>Quels \u00e9taient les r\u00e9sultats?<\/h2>\n<p>Pour \u00e9valuer l\u2019<strong>efficacit\u00e9<\/strong> de ce vaccin, les r\u00e9sultats de deux groupes de brebis gravides, infect\u00e9es dans un cadre exp\u00e9rimental par <em>C. abortus<\/em>, ont \u00e9t\u00e9 compar\u00e9s\u202f: un groupe vaccin\u00e9 et un groupe t\u00e9moin (non vaccin\u00e9). Les donn\u00e9es sur les signes cliniques, le comportement, la temp\u00e9rature et le poids des agneaux ont \u00e9t\u00e9 compar\u00e9s.<\/p>\n<figure id=\"attachment_5315\" aria-describedby=\"caption-attachment-5315\" style=\"width: 652px\" class=\"wp-caption aligncenter\"><a href=\"https:\/\/aboutsmallruminants.com\/wp-content\/uploads\/2021\/06\/laboratory-vaccine-against-enzootic-abortion.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"wp-image-5315 size-full\" src=\"https:\/\/aboutsmallruminants.com\/wp-content\/uploads\/2021\/06\/laboratory-vaccine-against-enzootic-abortion.jpg\" alt=\"vaccin inactiv\u00e9 contre Chlamydia\" width=\"652\" height=\"367\" srcset=\"https:\/\/aboutsmallruminants.com\/wp-content\/uploads\/2021\/06\/laboratory-vaccine-against-enzootic-abortion.jpg 652w, https:\/\/aboutsmallruminants.com\/wp-content\/uploads\/2021\/06\/laboratory-vaccine-against-enzootic-abortion-300x169.jpg 300w\" sizes=\"auto, (max-width: 652px) 100vw, 652px\" \/><\/a><figcaption id=\"caption-attachment-5315\" class=\"wp-caption-text\">Avec le nouveau vaccin inactiv\u00e9, nous sommes en mesure de contr\u00f4ler l\u2019AEB de mani\u00e8re efficace et s\u00fbre.<\/figcaption><\/figure>\n<p>Les r\u00e9sultats ont montr\u00e9 une r\u00e9duction de 75\u202f% des signes cliniques et une r\u00e9duction de 55\u202f% de l\u2019excr\u00e9tion dans le groupe vaccin\u00e9 par rapport au groupe non vaccin\u00e9. De plus, un effet positif a \u00e9t\u00e9 observ\u00e9 sur <strong>la prise de poids chez les agneaux<\/strong>.<\/p>\n<blockquote class=\"pullquote align-center\"><p><strong><span style=\"font-size: 20pt;\">\u00abLes r\u00e9sultats ont confirm\u00e9 qu\u2019INMEVA r\u00e9duit les signes cliniques et l\u2019excr\u00e9tion\u00bb\u00a0<\/span><\/strong><\/p><\/blockquote>\n<p>En termes de s\u00e9curit\u00e9, aucun effet ind\u00e9sirable significatif n\u2019a \u00e9t\u00e9 not\u00e9 au sein du groupe vaccin\u00e9.<\/p>\n<p>&nbsp;<\/p>\n<h2>Conclusions<\/h2>\n<p>Le <a href=\"https:\/\/aboutsmallruminants.com\/fr\/vaccination-avortement-enzootique-ovin\/\" target=\"_blank\" rel=\"noopener noreferrer\">vaccin commercial inactiv\u00e9<\/a> INMEVA\u00a0est s\u00fbr et pr\u00e9sente un <strong>niveau satisfaisant de protection<\/strong> contre <em>Chlamydia abortus<\/em>.<\/p>\n<p>Les effets suivants du vaccin ont \u00e9t\u00e9 observ\u00e9s pendant l\u2019\u00e9tude\u202f:<\/p>\n<p style=\"padding-left: 40px;\"><strong>\u25cf R\u00e9duction des signes cliniques dans la reproduction.<\/strong><br \/>\n<strong>\u25cf R\u00e9duction de l\u2019excr\u00e9tion chlamydienne.<\/strong><br \/>\n<strong>\u25cf Minimisation de la perte de poids des agneaux.<\/strong><br \/>\n<strong>\u25cf Aucun effet ind\u00e9sirable.<\/strong><\/p>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Chlamydia abortus est le pathog\u00e8ne \u00e0 l\u2019origine de l\u2019avortement enzootique des brebis (AEB), une maladie d\u2019une grande importance \u00e9conomique \u00e0 l\u2019\u00e9chelle mondiale. En 2019, un nouveau vaccin inactiv\u00e9 contre l\u2019AEB a \u00e9t\u00e9 lanc\u00e9\u202f: INMEVA. Dans cet article, nous pr\u00e9sentons les r\u00e9sultats d\u2019une \u00e9tude publi\u00e9e r\u00e9cemment dans la revue scientifique prestigieuse Frontiers in Veterinary Science, qui [&hellip;]<\/p>\n","protected":false},"author":5,"featured_media":5315,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[36],"tags":[],"class_list":["post-5348","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-reproduction"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v26.5 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>\u00c9valuation d\u2019un nouveau vaccin inactiv\u00e9 contre les Chlamydia<\/title>\n<meta name=\"description\" content=\"Cette \u00e9tude d\u00e9montre que le vaccin inactiv\u00e9 INMEVA est efficace et s\u00fbr contre Chlamydia abortus. 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