{"id":6253,"date":"2021-12-14T11:56:19","date_gmt":"2021-12-14T11:56:19","guid":{"rendered":"https:\/\/aboutsmallruminants.com\/?p=6253"},"modified":"2021-12-14T11:56:19","modified_gmt":"2021-12-14T11:56:19","slug":"vaccin-protection-avortements-salmonella","status":"publish","type":"post","link":"https:\/\/aboutsmallruminants.com\/fr\/vaccin-protection-avortements-salmonella\/","title":{"rendered":"Provoquer un vaccin : \u00c0 quoi ressemble la meilleure protection contre les avortements \u00e0 salmonella ?"},"content":{"rendered":"
Salmonella Abortusovis<\/em> est l\u2019un des principaux responsables des avortements chez les ovins<\/a>, en particulier en Europe et dans l\u2019ouest de l\u2019Asie, m\u00eame si des cas ont \u00e9t\u00e9 rapport\u00e9s dans le monde entier. Dans cet examen par des pairs, un groupe de scientifiques a \u00e9valu\u00e9 la s\u00e9curit\u00e9 et l\u2019efficacit\u00e9 du nouveau vaccin d\u2019HIPRA pour contr\u00f4ler et pr\u00e9venir l\u2019avortement \u00e0 Salmonella Abortusovis<\/em><\/a>.<\/em> Les r\u00e9sultats obtenus sont-ils prometteurs ?
\n<\/strong><\/div>\n

 <\/p>\n

Le pathog\u00e8ne<\/h2>\n

L\u2019avortement \u00e0 Salmonella Abortusovis<\/em> est une maladie qui affecte les brebis, et qui est caus\u00e9e par Salmonella enterica serovar Abortusovis. Il provoque des fausses couches tardives, la naissance d\u2019agneaux pr\u00e9matur\u00e9s et une mortalit\u00e9 n\u00e9onatale.<\/p>\n

\"\"<\/p>\n

Il s\u2019agit d\u2019un probl\u00e8me important pour la reproduction, susceptible d\u2019avoir un impact \u00e9conomique<\/a> \u00e9norme et d\u2019affecter le bien-\u00eatre des animaux. Les animaux infect\u00e9s excr\u00e8tent S. Abortusovis<\/em> dans le colostrum, le lait, les f\u00e8ces, et apr\u00e8s les fausses couches, \u00e0 travers les placenta, les s\u00e9cr\u00e9tions vaginales et les f\u0153tus.<\/p>\n

Pour contr\u00f4ler la maladie, il existe des vaccins att\u00e9nu\u00e9s et inactiv\u00e9s, mais dont la s\u00e9curit\u00e9 et l\u2019efficacit\u00e9, respectivement, ont toujours \u00e9t\u00e9 mises en doute.<\/p>\n

 <\/p>\n

Comment l\u2019\u00e9tude a-t-elle \u00e9t\u00e9 men\u00e9e\u00a0?<\/h2>\n

L\u2019objectif de cette \u00e9tude \u00e9tait d\u2019\u00e9valuer l\u2019efficacit\u00e9 du nouveau vaccin inactiv\u00e9 contre S. abortusovis (il comprend \u00e9galement Chlamydia abortus<\/em><\/a>).<\/p>\n

\u00c0 cette fin, les r\u00e9sultats d\u2019un groupe de brebis vaccin\u00e9 (n =17) ont \u00e9t\u00e9 compar\u00e9s \u00e0 un autre groupe de contr\u00f4le (n=20). Les param\u00e8tres surveill\u00e9s ont \u00e9t\u00e9\u00a0: incidence des fausses couches, excr\u00e9tion vaginale (PCR), survie des agneaux et r\u00e9ponse humorale (ELISA).<\/p>\n

\u201cUne caract\u00e9ristique reconnue des vaccins inactiv\u00e9s est leur s\u00e9curit\u00e9\u201d.
\n<\/span><\/strong><\/p><\/blockquote>\n

 <\/p>\n

Quels ont \u00e9t\u00e9 les r\u00e9sultats obtenus\u00a0?<\/h2>\n

Les r\u00e9sultats<\/strong> ont montr\u00e9 une diminution significative du nombre de fausses couches dans le groupe des brebis vaccin\u00e9es, dans lequel 5\u00a0animaux\/17 (29,4\u00a0%) ont souffert d\u2019une fausse couche\u00a0; en comparaison, le groupe de contr\u00f4le a pr\u00e9sent\u00e9 13\u00a0fausses couches\/20 (65\u00a0%).<\/p>\n

L\u2019autre point important est la survie des agneaux<\/strong>, qui s\u2019est \u00e9galement av\u00e9r\u00e9e sup\u00e9rieure dans le groupe vaccin\u00e9.<\/p>\n

\"\"<\/p>\n

Ill 1.<\/strong> R\u00e9sultats pour l\u2019excr\u00e9tion de S. Abortusovis (Log ufc\/ml): ScienceDirect<\/a>
\n<\/em><\/p>\n

 <\/p>\n

Des r\u00e9sultats prometteurs ont \u00e9galement \u00e9t\u00e9 observ\u00e9s en ce qui concerne l\u2019excr\u00e9tion<\/strong>. Le pourcentage de PCR positives comme la quantit\u00e9 de S.abortus<\/em> excr\u00e9t\u00e9e (Log ufc\/ml) \u00e9taient significativement inf\u00e9rieurs dans le groupe vaccin\u00e9.<\/p>\n

En outre, le vaccin n\u2019a provoqu\u00e9 aucun type d\u2019effet ind\u00e9sirable<\/strong> (augmentation de la temp\u00e9rature, signes cliniques\u2026), en dehors d\u2019une l\u00e9g\u00e8re r\u00e9action locale.<\/p>\n

Le vaccin fournit une stimulation ad\u00e9quate de la r\u00e9ponse humorale, ce qui indique une immunit\u00e9 active.
\n<\/span><\/strong><\/p><\/blockquote>\n

 <\/p>\n

Que pouvons-nous conclure\u00a0?<\/h2>\n

Cette \u00e9tude a montr\u00e9 que ce vaccin inactiv\u00e9 est s\u00fbr et efficace<\/strong> pour contr\u00f4ler deux des principaux aspects de l\u2019infection \u00e0 S. Abortusovis\u00a0:<\/p>\n

\u25cf Il r\u00e9duit le taux de fausses couches<\/strong>.
\n\u25cf Il r\u00e9duit l\u2019excr\u00e9tion<\/strong>.<\/p>\n

Par cons\u00e9quent, ce vaccin est un outil pr\u00e9cieux pour pr\u00e9venir et contr\u00f4ler<\/strong> la maladie et r\u00e9duire ainsi son impact \u00e9conomique<\/strong>.<\/p>\n","protected":false},"excerpt":{"rendered":"

Salmonella Abortusovis est l\u2019un des principaux responsables des avortements chez les ovins, en particulier en Europe et dans l\u2019ouest de l\u2019Asie, m\u00eame si des cas ont \u00e9t\u00e9 rapport\u00e9s dans le monde entier. Dans cet examen par des pairs, un groupe de scientifiques a \u00e9valu\u00e9 la s\u00e9curit\u00e9 et l\u2019efficacit\u00e9 du nouveau vaccin d\u2019HIPRA pour contr\u00f4ler et […]<\/p>\n","protected":false},"author":10,"featured_media":6278,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[36],"tags":[],"class_list":["post-6253","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-reproduction"],"yoast_head":"\nEfficacit\u00e9 et s\u00e9curit\u00e9 d\u2019un nouveau vaccin contre Salmonella Abortusovis<\/title>\n<meta name=\"description\" content=\"\u00c9valuation de l\u2019efficacit\u00e9 et de la s\u00e9curit\u00e9 d\u2019un nouveau vaccin contre Salmonella Abortusovis. 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