{"id":6253,"date":"2021-12-14T11:56:19","date_gmt":"2021-12-14T11:56:19","guid":{"rendered":"https:\/\/aboutsmallruminants.com\/?p=6253"},"modified":"2026-05-13T07:07:09","modified_gmt":"2026-05-13T07:07:09","slug":"vaccin-protection-avortements-salmonella","status":"publish","type":"post","link":"https:\/\/aboutsmallruminants.com\/fr\/vaccin-protection-avortements-salmonella\/","title":{"rendered":"Provoquer un vaccin : \u00c0 quoi ressemble la meilleure protection contre les avortements \u00e0 salmonella ?"},"content":{"rendered":"
Salmonella Abortusovis<\/em> est l\u2019un des principaux responsables des avortements chez les ovins<\/a>, en particulier en Europe et dans l\u2019ouest de l\u2019Asie, m\u00eame si des cas ont \u00e9t\u00e9 rapport\u00e9s dans le monde entier. Dans cet examen par des pairs, un groupe de scientifiques a \u00e9valu\u00e9 la s\u00e9curit\u00e9 et l\u2019efficacit\u00e9 du nouveau vaccin d\u2019HIPRA pour contr\u00f4ler et pr\u00e9venir l\u2019avortement \u00e0 Salmonella Abortusovis<\/em><\/a>.<\/em> Les r\u00e9sultats obtenus sont-ils prometteurs ?
\n<\/strong><\/div>\n

 <\/p>\n

Le pathog\u00e8ne<\/h2>\n

L\u2019avortement \u00e0 Salmonella Abortusovis<\/em> est une maladie qui affecte les brebis, et qui est caus\u00e9e par Salmonella enterica serovar Abortusovis. Il provoque des fausses couches tardives, la naissance d\u2019agneaux pr\u00e9matur\u00e9s et une mortalit\u00e9 n\u00e9onatale.<\/p>\n

\"\"<\/p>\n

Il s\u2019agit d\u2019un probl\u00e8me important pour la reproduction, susceptible d\u2019avoir un impact \u00e9conomique<\/a> \u00e9norme et d\u2019affecter le bien-\u00eatre des animaux. Les animaux infect\u00e9s excr\u00e8tent S. Abortusovis<\/em> dans le colostrum, le lait, les f\u00e8ces, et apr\u00e8s les fausses couches, \u00e0 travers les placenta, les s\u00e9cr\u00e9tions vaginales et les f\u0153tus.<\/p>\n

Pour contr\u00f4ler la maladie, il existe des vaccins att\u00e9nu\u00e9s et inactiv\u00e9s, mais dont la s\u00e9curit\u00e9 et l\u2019efficacit\u00e9, respectivement, ont toujours \u00e9t\u00e9 mises en doute.<\/p>\n

 <\/p>\n

Comment l\u2019\u00e9tude a-t-elle \u00e9t\u00e9 men\u00e9e\u00a0?<\/h2>\n

L\u2019objectif de cette \u00e9tude \u00e9tait d\u2019\u00e9valuer l\u2019efficacit\u00e9 du nouveau vaccin inactiv\u00e9 contre S. abortusovis (il comprend \u00e9galement Chlamydia abortus<\/em><\/a>).<\/p>\n

\u00c0 cette fin, les r\u00e9sultats d\u2019un groupe de brebis vaccin\u00e9 (n =17) ont \u00e9t\u00e9 compar\u00e9s \u00e0 un autre groupe de contr\u00f4le (n=20). Les param\u00e8tres surveill\u00e9s ont \u00e9t\u00e9\u00a0: incidence des fausses couches, excr\u00e9tion vaginale (PCR), survie des agneaux et r\u00e9ponse humorale (ELISA).<\/p>\n

\u201cUne caract\u00e9ristique reconnue des vaccins inactiv\u00e9s est leur s\u00e9curit\u00e9\u201d.
\n<\/span><\/strong><\/p><\/blockquote>\n

 <\/p>\n

Quels ont \u00e9t\u00e9 les r\u00e9sultats obtenus\u00a0?<\/h2>\n

Les r\u00e9sultats<\/strong> ont montr\u00e9 une diminution significative du nombre de fausses couches dans le groupe des brebis vaccin\u00e9es, dans lequel 5\u00a0animaux\/17 (29,4\u00a0%) ont souffert d\u2019une fausse couche\u00a0; en comparaison, le groupe de contr\u00f4le a pr\u00e9sent\u00e9 13\u00a0fausses couches\/20 (65\u00a0%).<\/p>\n

L\u2019autre point important est la survie des agneaux<\/strong>, qui s\u2019est \u00e9galement av\u00e9r\u00e9e sup\u00e9rieure dans le groupe vaccin\u00e9.<\/p>\n

\"\"<\/p>\n

Ill 1.<\/strong> R\u00e9sultats pour l\u2019excr\u00e9tion de S. Abortusovis (Log ufc\/ml): ScienceDirect<\/a>
\n<\/em><\/p>\n

 <\/p>\n

Des r\u00e9sultats prometteurs ont \u00e9galement \u00e9t\u00e9 observ\u00e9s en ce qui concerne l\u2019excr\u00e9tion<\/strong>. Le pourcentage de PCR positives comme la quantit\u00e9 de S.abortus<\/em> excr\u00e9t\u00e9e (Log ufc\/ml) \u00e9taient significativement inf\u00e9rieurs dans le groupe vaccin\u00e9.<\/p>\n

En outre, le vaccin n\u2019a provoqu\u00e9 aucun type d\u2019effet ind\u00e9sirable<\/strong> (augmentation de la temp\u00e9rature, signes cliniques\u2026), en dehors d\u2019une l\u00e9g\u00e8re r\u00e9action locale.<\/p>\n

Le vaccin fournit une stimulation ad\u00e9quate de la r\u00e9ponse humorale, ce qui indique une immunit\u00e9 active.
\n<\/span><\/strong><\/p><\/blockquote>\n

 <\/p>\n

Que pouvons-nous conclure\u00a0?<\/h2>\n

Cette \u00e9tude a montr\u00e9 que ce vaccin inactiv\u00e9 est s\u00fbr et efficace<\/strong> pour contr\u00f4ler deux des principaux aspects de l\u2019infection \u00e0 S. Abortusovis\u00a0:<\/p>\n

\u25cf Il r\u00e9duit le taux de fausses couches<\/strong>.
\n\u25cf Il r\u00e9duit l\u2019excr\u00e9tion<\/strong>.<\/p>\n

Par cons\u00e9quent, ce vaccin est un outil pr\u00e9cieux pour pr\u00e9venir et contr\u00f4ler<\/strong> la maladie et r\u00e9duire ainsi son impact \u00e9conomique<\/strong>.<\/p>\n","protected":false},"excerpt":{"rendered":"

Evaluation of the effectiveness and safety of a new vaccine against Salmonella Abortusovis: The vaccine is a good tool against the pathogen .<\/p>\n","protected":false},"author":10,"featured_media":6278,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[36],"tags":[88],"class_list":["post-6253","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-reproduction","tag-restricted"],"yoast_head":"\nEffectiveness and safety of a new Salmonella Abortusovis vaccine<\/title>\n<meta name=\"description\" content=\"Evaluation of the effectiveness and safety of a new vaccine against Salmonella Abortusovis: The vaccine is a good tool against the pathogen.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" 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